bromodomain in 1 — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T10620	Bromodomain IN-1		Others
	Bromodomain IN-1 is an inhibitor of Bromodomain.		Others
T10717	Inobrodib	CBP-IN-1	Epigenetic Reader Domain
	Inobrodib (CBP-IN-1) is a potent inhibitor of p300/CBP bromodomain.		Epigenetic Reader Domain
T9552	BAZ1A-IN-1		Epigenetic Reader Domain
	BAZ1A-IN-1 is a potent BAZ1A inhibitor with the KD value of 0.52 μM for the BAZ1A bromodomain. BAZ1A-IN-1 shows good anti-survival activity against cancer cell lines with high BAZ1A expression, but weak or no activity ag...		Epigenetic Reader Domain
T63767	P300 bromodomain-IN-1
	P300 bromodomain-IN-1 is a potent inhibitor of p300 (EP300) bromodomain (IC50: 49 nM). p300 bromodomain-IN-1 blocks c-Myc expression and induces cell cycle arrest at G1/G0 phase and apoptosis in OPM-2 cells. apoptosis).
T7264	CBP/EP300-IN-1		Epigenetic Reader Domain
	CBP/EP300-IN-1 is a CBP/EP300 bromodomain inhibitor.		Epigenetic Reader Domain
T6222	PFI-1	PF-6405761,PFI 1,PFI1	Apoptosis , Epigenetic Reader Domain , Autophagy
	PFI-1 (PF-6405761), a specific BET (bromodomain-containing protein) inhibitor for BRD4, is with the IC50 of 0.22 μM in a cell-free assay.		Apoptosis , Epigenetic Reader Domain , Autophagy
T19618	(R)-(-)-JQ1 Enantiomer		Epigenetic Reader Domain
	(R)-(-)-JQ1 Enantiomer is the stereoisomer of (+)-JQ1. (+)-JQ1 is a BET bromodomain inhibitor, acting on BRD4(1/2)(IC50 of 77 nM/33 nM in a cell-free assay)		Epigenetic Reader Domain
T60155	PBRM1-BD2-IN-7		Epigenetic Reader Domain
	PBRM1-BD2-IN-7, a selective and cell-active inhibitor targeting the polybromo-1 (PBRM1) bromodomain, demonstrates inhibitory efficacy against PBRM1-BD2 with an IC50 value of 0.29 μM. This compound is utilized in cancer r...		Epigenetic Reader Domain
T4247	I-CBP112 hydrochloride		Epigenetic Reader Domain
	I-CBP112 is a selective inhibitor of the bromodomain-containing transcription factors. I-CBP112 (1 mM) has little activity against other bromodomains. I-CBP112 targets the CBP/p300 bromodomains. I-CBP112 significantly re...		Epigenetic Reader Domain
T60156	PBRM1-BD2-IN-2		Epigenetic Reader Domain
	PBRM1-BD2-IN-2, a selective and cell-active inhibitor of the polybromo-1 (PBRM1) bromodomain, exhibits binding affinity and inhibitory activity specifically targeting the PBRM1-BD2 domain, with Kd and IC50 values of 9.3 ...		Epigenetic Reader Domain
T9703L	GSK778 hydrochloride		Epigenetic Reader Domain
	GSK778 hydrochloride hydrochloride is a potent and selective BD1 bromodomain inhibitor of the BET proteins, with IC50s of 75 nM (BRD2 BD1), 41 nM (BRD3 BD1), 41 nM (BRD4 BD1), and 143 nM (BRDT BD1), respectively. GSK778 ...		Epigenetic Reader Domain
T10773	CF53		Epigenetic Reader Domain , CDK
	CF53 is a highly potent, selective and orally active inhibitor of BET protein, with a Ki of <1 nM, Kd of 2.2 nM and an IC50 of 2 nM for BRD4 BD1. CF53 binds to both the BD1 and BD2 domains of BRD2, BRD3, BRD4, and BRDT B...		Epigenetic Reader Domain , CDK
T39634	GSK097
	GSK097 is a highly potent and selective inhibitor of the second bromodomain (BD2) found in bromodomain and extra-terminal domain (BET) proteins. It exhibits a remarkable 2000-fold selectivity for BD2 over BD1, as indicat...
T79093	Bromodomain inhibitor-12		Epigenetic Reader Domain
	Bromodomain Inhibitor-12 (example 303) is a research compound utilized in the study of autoimmune and inflammatory diseases [1].		Epigenetic Reader Domain
T79084	BET bromodomain inhibitor 3		Epigenetic Reader Domain
	BET Bromodomain Inhibitor 3 is a BET bromodomain inhibitor with an inhibitory Ki value of >40 µM against BrdT. It is utilized in research related to contraception, cancer, and heart disease [1].		Epigenetic Reader Domain
T63220	Bromodomain inhibitor-9
	Bromodomain inhibitor-9 is an inhibitor of Bromodomains that selectively inhibits the activity of BRD4-1 with a Kd value of 12 nM. Bromodomain inhibitor-9 can be used in studies of diseases related to systemic or lipid m...
T15399	GNE-207		Epigenetic Reader Domain
	GNE-207 is a selective and orally bioavailable inhibitor of the bromodomain of CBP (IC50: 1 nM). It has a selective index of >2500-fold against BRD4 (1). GNE-207 displays excellent CBP potency (EC50: 18 nM for MYC expres...		Epigenetic Reader Domain
T77680	BRD7-IN-3		Epigenetic Reader Domain
	BRD7-IN-3 (compound 1-78) functions as a dual inhibitor targeting the bromodomain-containing proteins BRD7 and BRD9, demonstrating half-maximal inhibitory concentrations (IC50s) of 1.6 μM for BRD7 and 2.7 μM for BRD9, re...		Epigenetic Reader Domain
T74823	Bromodomain IN-2
	BD-IN-1, a pan bromodomain (BD) inhibitor, exhibits K_D values of 250 nM for BRD4(1), 420 nM for CBP, 130 nM for BRPF1B, 430 nM for BRD7, 67 nM for BRD9, 240 nM for BRDT(1), and 970 nM for CECR2, respectively. This compo...
T75170	BI01826025
	BI01826025 (pArg-JQ1), a PROTAC degrader targeting the bromodomain 1 of BRDT (BRDT BD1), proves useful in exploring the regulatory impact of ClpC2 on the ClpC1P1P2 protease complex [1].